Alopecia areata y vitamina D sérica en pacientes iraquíes: un estudio de casos y controles / Alopecia Areata And Serum Vitamin D in Iraqi Patients: a case-control study

Background: Alopecia areata (AA) is a typical hair issue, which may have obliterating mental and social outcomes and is portrayed by the nearness of nonscarring alopecia. Objective: This examination has targets to assess the serum nutrient D levels , with AA; contrast the outcome and clearly sound control; and confirm relationship between AA types and serum nutrient D levels. Patients Also Methods: the examine might have been led clinched alongside Tikrit educating healing facility throughout those time starting with June 2019 of the limit for January 2020. Irrefutably the quantity of subjects associated with the assessment was ninety individuals isolated in two social events; the patients bundle were forty five the people who whimper of AA while the resulting gathering including a forty five age and sex-made solid volunteers were picked as a benchmark gathering. The degree and movement of the alopecia were noted and the patients were meticulously broke down for signs of various ailments. Research center assessments were led to patients and also to those control population, these included serum vitamin D levels were measured as 25-hydroxyvitamin D {25(OH)D} using a chemiluminescence microparticle immunoassay. Blood models were gotten starting with patients and control subjects after totally taught consent was gotten. Results : An essential complexity may have been found for serum 25-OH Vit D levels between patients other than controls. Vitamin D sufficiency were more common in controls than in patients. Serum Vitamin D was deficient in both cases and controls group; but, the deficiency was significantly more throughout AA group (35. 6%) compared to the handle group (11. 1%). Among the list patients gathering, levels associated with nutrient D were totally higher in guys in contrast with females. Conclusions: AA might be related with nutrient D deficiency as mean degrees of nutrient D of patients were seen as fundamentally lower than typical sound controls.

Significado laboratorial dos baixos títulos de VDRL para o diagnóstico da sífilis em gestantes, à luz das provas treponêmicas / Laboratorial meaning of low titles of VDRL to syphilis diagnosis in pregnant women, according to treponemal tests

Introdução: a melhor prevenção para sífilis congênita possivelmente seja a realização dos testes de triagem durante o pré-natal, principalmente nas mulheres consideradas de comportamento de risco para a infecção pelo HIV e demais DST. Para o obstetra, a importância dessa doença transcende seus aspectos clínicos, principalmente pela transmissão vertical de seu agente etiológico. Desta forma, o diagnóstico laboratorial precoce e correto é uma poderosa ferramenta na profilaxia da sífilis congênita. Objetivo: estabelecer o significado dos baixos títulos para o teste de VDRL frente aos testes treponêmicos em gestantes. Métodos: foram analisadas 215 amostras de soro de gestantes de duas maternidades da cidade do Rio de Janeiro, RJ. Utilizou-se o teste VDRL e testes treponêmicos (TPHA, ELISA e Western-blotting). Os títulos de VDRL foram confrontados com testes não-reagentes, tendo como variável independente os testes treponêmicos. Resultados: houve associação estatisticamente significativa (?<0,05) entre os diversos títulos de VDRL (baixos títulos:1/1, 1/2 e 1/4 e altos títulos: ?1/8) quando confrontados com os testes treponêmicos. Por meio da análise comparativa de sensibilidade e especificidade obteve-se a curva ROC (Receiver Operator Characteristic). Títulos de VDRL acima de 1/1 associaram-se, de modo significativo, com os testes treponêmicos. Conclusão: os resultados mostraram que os baixos títulos de VDRL devem ser valorizados e que o teste considerado como screening pode também ser útil quando utilizado como teste diagnóstico para asífilis em gestantes.

Current Status of External Quality Assessment of Syphilis Test in Korea / 대한진단검사의학회지

BACKGROUND: Current status of external quality assessment (EQA) of laboratory tests for syphilis in Korea was analyzed to find out the problems that should be improved in the future. METHODS: Based on the data from the external quality assessment program performed twice a year by the Immunoserology Subcommittee of the Korean Association of Quality Assurance for Clinical Laboratory from the year 2004 to 2006, discordance rates were analyzed according to the test method and commercial kit used. RESULTS: Among the laboratories participating in the EQA program for syphilis test, about 90% of them used non-treponemal tests and about 55% treponemal tests. The non-treponemal tests included RPR (rapid plasma reagin) and VDRL tests used in 88% (363/412) and 11% (45/412), respectively, of the laboratories. The discordance rates were 2.2% for RPR test and 3.6% for VDRL. For the treponemal tests, Treponema pallidum hemagglutination assay (TPHA) was used in 60-76% and Immunochromatography assay (ICA) in about 30% of the laboratories in 2006. A high discordance rate of over 10% was reported in both TPHA and in ICA methods, possibly due to a low titer (1:1 in VDRL) of EQA samples in 2005. Analysis of the accumulated data from year 2004 to 2006 showed that the discordance rates of TPHA, ICA, and FTA-ABS were 4.6%, 3.7%, and 2.7%, respectively. CONCLUSIONS: For syphilis tests, RPR test, TPHA, and ICA are mainly used in Korea. A high discordance rate is still reported in TPHA and ICA, especially when testing samples with a low titer. Further analysis of data and education of laboratory personnel are needed for the improvement of the EQA program.

Sífilis congénita en el Servicio de Salud Metropolitano Sur: pesquisa de casos / Congenital syphilis in the south metropolitan health area: case surveillance

Sífilis congénita es una enfermedad absolutamente prevenible mediante la pesquisa de la infección en la mujer embarazada. Más de la mitad de los recién nacidos infectados son asintomáticos al nacer 'y, al no disponer de in test diagnóstico que permita asegurar o descartar la infección en el recién nacido, el diagnóstico es complejo, debiendo éste basarse en elementos clínicos, serológicos y epidemiológicos, no siempre disponibles, lo que probablemente lleva a subnotificación de esta infección. Sugerimos por esto adoptar la recomendación actual del CDC de E.U.A. que permite definir, tratar y notificar un caso de sífilis congénita al nacer, evitando el riesgo de no tratar a recién nacidos infectados por no cumplimiento del seguimiento posterior

FTA-ABS y VDRL en suero y líquido cefalorraquideo de pacientes con carate / FTA-ABS and VDRL in serum and spinal fluid of patients with late pinta

En 41 pacientes con carate tardío se hace un estudio comparativo entre el FTA-ABS y el VDRL en suero y LCR. En suero el VDRL fue reactivo en 48% de los casos y el FTA-ABS en 68%. Ambas pruebas fueron siempre negativas en LCR. Se hace una corta discusión sobre los resultados y revisión de la literatura

Evaluacion serologica para sifilis en pacientes tuberculosos / Serologic evaluation for syphilis in patients with pulmonary tuberculosis

Con el objeto de reevaluar la frecuencia de falsos positivos de serologia para sifilis en pacientes tuberculosos, se estudiaron 125 pacientes de ambos sexos, con edades que fluctuaron entre los 15 y los 78 anos, 78 de ellos con ano o menos de evolucion de la tuberculosis y 47 de mas de un ano con su enfermedad. Como controles se estudiaron 3.866 sueros de pacientes sin evidencia clinica, actual o pasada, de sifilis o tuberculosis (TBC). Los pacientes tuberculosos y el grupo control fueron sometidos a pruebas no treponemicas VDRL (venereal disease research laboratory) y RPR (rapid plasma reagent) asi como a la prueba treponemica MHA-TP (microaglutinacion para Treponema Pallidum). Los resultados obtenidos, 1,3% de falsos positivos en la poblacion control vs. 1,6% en los pacientes tuberculosos, confirman nuestra creencia de que la tuberculosis no es causa importante de falsos positivos en serologia no treponemica